How Does Metformin Work for PCOS?
Polycystic ovary syndrome (PCOS) is diagnosed in every tenth women at the age of over 18. It is one of the most common endocrine diseases of women of the reproductive age. However, according to the National Institutes of Health about 70% of women with this diagnosis do not even suspect any pathologies.
It is still unknown what causes the PCOS. There is an opinion about a role of the genetics and environment. But women who have had this disease maternally or paternally in the family are at a higher risk. Diabetes mellitus also increases a risk of this syndrome.
About 70% of women with Polycystic Ovary Syndrome have a disorder of the response to insulin. This resistance (a reduced sensitivity) to insulin may lead to the development of diabetes mellitus type 2. This connection works in reverse. One of the causes of PCOS is an insulin-resistance.
A compensatory hyperinsulinemia happens during this diagnosis, and it stimulates the production of the androgens by ovaries in women, who have a genetic tendency to the PCOS. In other words, the excess amount of insulin appears in the female body, and it leads to the hormone disorder and a development of PCOS.
Due to this, Metformin is one of the most effective drugs for the treatment of the PCOS. It is explained by the fact that the pharmacological action of Metformin consists in the inhibition of the insulin-resistance and a reduction of the insulin production.
In case of the low insulin level in the blood and a reduction of the glucose level, a woman have a recovery of the lipid balance as well as metabolism. Due to this, the excessive action of insulin on the cells of the ovaries is reduced, and they start to gradually restore its function.
The following processes are observed due to the recovery of the ovary functions:
- Ovulation recovery;
- Menstruation improvement;
- Reduced level of the androgenic hormones;
- Increased level of the gonadotropic hormones.
The increase of LH and FSH which happens due to the use of Metformin provides a recovery of the female fertility.
However, Metformin during PCOS is taken not only for the recovery of the reproductive function in women, but also for the reduction of a risk of hyperplasia and endometrium cancer. A long-term increase of the androgenic hormones of women increases a risk of the cardiovascular diseases including the arterial hypertension.
Therefore, a pharmaceutical therapy with the use of Metformin provides a complex action not only on the functions of the genitals but also on the cardiovascular system improving the heart health and the life quality of patients with diabetes and polycystic ovary syndrome.
How Many mg of Metformin Should I Take for PCOS?
A majority of doctors recommend the standard doses of Metformin during PCOS. This is 1000-1500 mg of Metformin per day depending on the glucose level in the blood, insulin level and the additional complications. However, the experienced studies and reviews of women have confirmed that the standard doses of Metformin are ineffective during PCOS.
A minimal dose of Metformin should be 1000 mg during the treatment of the polycystic ovary syndrome, and a daily dose should be at least 2000 mg. Most women state that the use of 2,5 g Metformin per day has brought changes.
This has an explanation: low doses are enough to adjust the glucose level in the blood due to the complex action of Metformin. In order to restore the ovary functions, this dose is not enough. It is necessary to achieve the maximal inhibition of the insulin-resistance.
What are the Side Effects of Metformin for PCOS?
The high doses of Metformin during the PCOS slightly increase risks of the side effects. However, if all precautions are followed, they do not give any discomfort over time. You should understand that the side effects grow during the use of more than 2500 mg per day, and during the kidney diseases.
Women taking Metformin in high doses to treat the PCOS usually have the following symptoms:
- Nausea, flatulency, discomfort, and diarrhea;
- Light headache;
- Skin itching, rash.
The most dangerous side effect of Metformin is lactic acidosis. It is a state when the lactic acid is accumulated in the tissues and blood. The symptoms of this state are muscle pain, shortness of breath, numbness of limbs, paleness, and heart beat disorder. If these symptoms occurred, the use of Metformin should be stopped and the level of the lactic acid should be checked in the blood.
Can Metformin Help You Lose Weight with PCOS? Metformin PCOS Diet
Due to the metabolic disorders related to the polycystic ovary syndrome, many women have the obesity. The treatment of the obesity is complicated by diabetes mellitus type 2 which appears due to the insulin-resistance.
The use of the intensive inhibitors of the appetite is contraindicated during the diabetes and PCOS because it may complicate the course of the disease. Therefore, Metformin and diet-therapy are the main methods to fight the obesity.
However, Metformin cannot be considered as the basic product to lose weight. It is just an additional tool during the low-calorie diet which will help to accelerate the metabolism and increase the utilization of the fats in the muscle tissue.
But as the last studies show, Metformin is able to reduce the body mass in patients with the PCOS by 10% if the high physical activity and a low-carb diet are followed. It is achieved only in combination, and only if the body mass index exceeds 30. The less the patient has the percentage of the fat and the body mass index, the worse Metformin will work.
It is explained by the fact that this medication mainly affects the fatty tissue located on the belly. The visceral fat affects the work of the internal organs in this area. And the lower the percentage of the fat is in the body, the less amount of the fatty tissue is around the belly. It means the Metformin will not give the highest activity.
Buy Metformin for PCOS. How Does Metformin Help PCOS?
Metformin for polycystic ovaries, according to doctors, is a drug that is used when there is evidence of diabetes mellitus or in prediabetic condition.
Metformin with PCOS, according to reviews and established facts, is included in a group of drugs called biguanides. Today, it begins to be actively acquired by many patients during the treatment of polycystic ovary syndrome.
Treatment of polycystic ovaries with the help of buying and using Metformin is aimed at reducing the level of insulin produced in the blood in order to prevent endocrine disorders and restore hormonal balance in a woman's body.
Among the most famous and effective effects of Metformin for PCOS on the body are the following:
- The use of Metformin in PCOS affects the insulin production process and contributes to a significant decrease in body loyalty to glucose. This is very important, since glucose precedes the formation of diabetes.
- Metformin is useful for restoring the mechanism of glucose perception, thereby stabilizing the metabolism and improving the hormonal functioning of the body. At the same time, the indicator of a person’s weight decreases.
- The purchase and use of Metformin in PCOS also has a beneficial effect on the lipid composition of human blood, making it more susceptible to glucose uptake.
- Metformin in the instructions for use for polycystic ovary is not described as a drug against PCOS, but it is extremely useful because it responds to hormonal processes in the female body.
- In the process of treating polycystic ovary syndrome, Metformin helps restore ovulation and return a harmonious menstrual cycle. In other words, thanks to the purchase of Metformin for the treatment of PCOS, it is possible to return fertility and the ability to continue the race.
- Metformin with polycystic ovaries has an overwhelming effect on the increased production of male sex hormones. This ability of a medical preparation favorably affects the hormones of a woman with polycystic disease and helps to restore the functioning and harmonious work of the ovaries.
Buying this drug is helpful not only in diagnosing polycystic ovarian syndrome. This drug is also recommended as part of a treatment regimen for other inflammatory or abnormal processes in the female reproductive system.
Statistics show that over 80% of women treated with Metformin have stabilized their body weight during treatment, the hormonal balance has improved and the primary symptoms of diseases associated with the endocrine system have disappeared.
Here you have the answer to the question: "Do I need to buy Metformin for PCOS?". The answer is YES!
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