Controlling Type 2 Diabetes. Diabetes Treatment Guidelines. How to Take Metformin?

Contents

Diabetes Pills Metformin. Rules of Admission. Min and Max Doses

An insulin-resistant type of diabetes mellitus is well treatable, if this issue is properly approached and the right hypoglycemic products are taken. Metformin is the main product for the treatment of diabetes mellitus type 2.

Diabetes Pills Metformin

Main advantages of Metformin:

  • It does not increase the blood pressure and the load on the cardiac muscle.
  • It does not cause an appearance of an acute or delayed hypoglycemia.
  • It reduces the cholesterol level in the blood and the body mass.
  • It improves the walls of the blood vessels and their conductivity.

A patient does not experience an absolute deficit of insulin which should be regularly compensated with the help of injection during the diabetes mellitus type 2. Therefore, Metformin is effective during the mono-therapy and only during the worsening of the patient’s condition, insulin injections may be prescribed as an addition to Metformin.

Metformin is released in form of pills (regardless of a manufacturer) in the dose of 500 mg, 850 mg, and 1000 mg. A wide choice of the working doses is due to the fact that every patient needs an individual dose depending on a clinical pattern. This range of the doses allows to select the minimal working daily dose and divide it into 2 or 3 equal parts.

Moreover, the maximal daily dose should be equal to 2,5 g, and the minimal is 500 mg. You should select a dosing, so that it would be within these ranges. If a patient has a high level of glucose in the blood during the use of 2,5 g (2500 mg) Metformin, hypoglycemic drugs from other medical groups are prescribed (for example, medications of Sulfonylurea). If the function of the pancreatic gland is affected, a replacement therapy with insulin injections is prescribed.

But due to the combined medical therapy of diabetes mellitus type 2, a dose of every drug should be reduced. It means that using Metformin and insulin, it is necessary to prescribe the maximal dose of Metformin, and the minimal dose of insulin. A choice is made in favor of the safest medication that may cause the minimal harm for the body.

The Metformin pills should be taken every day during meals, but not more than 3 times per day. every pill should be taken with enough water, so that it will be digested in the gastro-intestinal tract faster.

  • Do not take the pill with sweet fizzy drinks, juice, or milk.

The medication should be taken during meals, so that the drug will begin to block the uptake of glucose in the intestine at once. If the pill is taken after meals, in about 1-2 hours, the effect from the use of the therapeutic dose will not be so intensive.

Important recommendations:

  • Metformin should be taken carefully by patient at the age of over 65;
  • Metformin may be taken in 2 hours after the physical activity. The use of the pills after the active physical training may cause a development of lactic acidosis;
  • Using Metformin, it is necessary to follow a low-carb diet but a patient should consume at least 1000 Kcal within a day. In case of strict diets, the sugar level drops up to the crucial level, and the signs of hypoglycemia appear;
  • Metformin is not prescribed for the treatment of diabetes mellitus in children under 10.

How Does Metformin Work in the Body? Metformin Action Time

It is today proved that an insulin-resistance is an authentic factor of risk of the cardiovascular diseases (combinations of these pathologies have got the name an insulin-resistant syndrome or X syndrome). It explains the effect of Metformin in a reduction of the development of the cardiovascular diseases.

how Metformin acts during diabetes mellitus type 2

To know how Metformin acts during diabetes mellitus type 2, it is necessary to find out why the body is not able to utilize glucose.

Insulin is a hormone produced in the pancreatic gland. It executes the transport function in our body. All carbohydrates that reach the body with food are split into glucose that goes to the blood. Insulin transfers glucose from the blood to the tissue cells, and this way the body is provided with the energy.

Due to the pathological processes in the body, cells lose the ability to interact with insulin and do not receive the glucose from it. Due to this, glucose is accumulated in the body, and the insulin-resistant diabetes mellitus appears.

As the body tries to synthesize more amount of insulin and effectively transfer the glucose, the cells do not accept it. The excessive amount of insulin is associated with the central obesity (the fat pad in the area of the belly), high level of cholesterol and/or hypertonia. Therefore, most patients with diabetes type 2 have the excessive body weight, various disorders of the lipid metabolism.

The main action of Metformin is its high sensitivity of the tissues to insulin. It means that every molecule of glucose sent by insulin hormone to the cells should be accepted and digested. The action of the drugs of sulfonylurea or injections of the exogenous insulin are directed at the compensation of the insufficient insulin secretion. In case of the insulin-resistance, there is no deficit of insulin, and therefore these drugs are ineffective but also dangerous because they may cause hypoglycemia.

Metformin may be only used as the drug to reduce the insulin-resistance if the insulin secretion is adequate. The advantage of Metformin as the initial drug for the treatment of diabetes consists in a moderate reduction of the body weight and an improvement of the lipid balance. It happens because the pancreatic gland stops synthesizing the excessive amount of insulin during the inhibition of the insulin-resistance, and all metabolic processes are improved.

It is clinically proved that patients have a lower glucose level, as well as insulin in the blood in 3 months after the use of Metformin.

To increase the effect, Metformin reduces a production of glucose in the liver and increases an utilization of it by the muscle tissue. It means that it affects not only glucose which has been received outside, but also the internal secretion of glucose that is required for the normal work of the body.

However, to reduce the load on the pancreatic gland, the intestine and liver, Metformin just blocks the uptake of some amount of carbs during eating. Due to this, these carbohydrates are not transformed into glucose and are excreted, and the patient’s body easily works with the amount of glucose that it gets.

Metformin for Obesity. Does Metformin Help with Weight Loss?

Diabetes mellitus type 2 and obesity are complementary pathologies. About 80% of people with obesity have diabetes mellitus, and on the contrary.

Metformin for obesity

As it was mentioned before, the development of diabetes mellitus type 2 and a sudden increase of the insulin synthesis may lead to the development of the obesity. But it often happens otherwise, and diabetes mellitus type 2 appears in patients who suffer from the obesity.

«Women with waist circumference more than 80 cm and men with waist circumference more than 94 cm have the high risks of diabetes»

The visceral fat is accumulated in the area of waist and belly, and the fatty tissue is accumulated around the organs of the abdominal cavity. Fat coats all internal organs and breaks metabolic processes. Due to the excessive fatty tissue, human has hormones of the fatty tissue adipokines that favor the increase of the insulin-resistance.

Therefore, it is necessary to pay attention to the work of the liver and pancreatic gland, and the functioning of the intestine and the body mass index for the effective treatment of diabetes mellitus. If the body mass index is more than 30, the treatment of diabetes mellitus is complicated, and patients will manage to stop the growth of the glucose concentration in the blood. In order to reduce the sugar level in the blood, it is necessary to get rid of the fat.

Therefore, Metformin is the most effective and universal product for the treatment of diabetes mellitus.

The main effect of Metformin during obesity is:

  • Slowing down the absorption of the glucose in the small bowel;
  • Reducing the fatty acid oxidation;
  • Accelerating the glucose utilization;
  • Increasing the uptake of the glucose by muscles.

Metformin stimulates metabolic processes in the body, as a result of which the muscles actively uptake the energy in the form of glucose. As the cells better take the activity of insulin, the glucose is quickly transferred into the tissues and its deficit appears. This small deficit is covered by means of the fat that is split to cover the energetic needs.

Besides the improvement of metabolism, Metformin also prevents the absorption of carbohydrates in the intestine that will be in the excessive amount, and that may cause the increase of the fatty tissue.

However, the action of Metformin is inferior to many drugs for the weight loss. The main effect of this medication is to reduce the glucose in the blood. So, to achieve the result and reduce the excessive fat, it is necessary to follow the low-carb diet. It will help to reduce the body mass and accelerate the lowering of the sugar level in the blood.

Metformin is the most commonly prescribed drug for treating diabetes mellitus. In addition, it is used to combat obesity and to get rid of polycystic ovary disease in gynecology. The drug allows you to lose weight, lowers blood sugar levels, but does not cause serious side effects.

Taking Metformin is a reliable prevention of the development of severe complications of diabetes mellitus, such as heart attack and stroke, thereby prolonging the life of patients. There is evidence that Metformin protects people from certain types of cancers.

The cost of the drug is low, since many pharmaceutical companies are engaged in its production.

When is Metformin prescribed?

Indications for taking Metformin, which are presented in the official instructions:

1. Diabetes mellitus type 2.

2. Type 1 diabetes mellitus in obese patients with insulin resistance.

However, in reality, many people take Metformin to lose weight. It is also prescribed for the treatment of polycystic ovary syndrome in women. This measure increases the patient’s chances of a successful conception.

In addition to taking the drug, women suffering from polycystic ovary syndrome should definitely follow a low-carb diet and exercise. This increases the chances of a successful conception.

Metformin: instructions for use.

Metformin is prescribed for type 2 diabetes mellitus, and sometimes in a complex treatment regimen for type 1 diabetes. The drug helps to reduce blood sugar both on an empty stomach and after meals, and also allows you to normalize the level of glycated hemoglobin.
Taking the drug makes it possible to reduce the production of glucose in the liver, and also prevents excessive absorption of carbohydrates in the intestine. Thanks to the intake of Metformin, it is possible to increase the sensitivity of cells to insulin. The pancreas does not produce an excessive amount of insulin during treatment, which prevents hypoglycemia from developing.

The drug does not accumulate in the body. Most of it is excreted by the kidneys. When a long-acting drug is used, for example, Glucophage Long, metformin is absorbed longer when compared with taking conventional tablets.
Provided that a person suffers from certain kidney pathologies, Metformin should be prescribed with caution.

The drug is prescribed for patients with type 2 diabetes mellitus, obese individuals with low cell sensitivity to insulin.
Treatment with metformin should be done with adequate physical activity and a low-carb diet.

Contraindications to treatment with Metformin:

1. Diabetic ketoacidosis.

2. Diabetic coma.

3. Renal failure with a glomerular infiltration rate of 45 ml / min and below.

4. The level of creatinine in the blood is 132 mol / l for men and 141 mol / l for women.

5. Liver failure.

6. Infectious diseases in the acute phase.

7. Alcoholism.

8. Dehydration of the body.

If the patient is to undergo surgery or X-ray examination using contrast, then he should stop taking Metformin 2 days before the procedure.
Sometimes patients can develop such a serious complication as lactic acidosis. This is accompanied by a drop in blood pH to 7.25, which poses a serious threat not only to health and life. Therefore, when symptoms such as abdominal pain, increased weakness, vomiting and shortness of breath appear, you need to call an ambulance.
As a rule, lactic acidosis develops only when a person has taken too much of the drug, or the treatment was carried out in the presence of contraindications. In other cases, Metformin therapy does not lead to the development of lactic acidosis.

How to take Metformin and in what dose?

Treatment should begin with a minimum dose of 500-850 mg of the drug per day. It is gradually increased and brought to 2550 mg per day, taking 1 tablet of 850 mg three times a day. The increase should occur once every 7-10 days.
If a person uses a drug with prolonged action for treatment, then the daily dose is reduced to 2000 mg. The drug is taken once a day, before bedtime.

Adverse effects from Metformin.

Side effects are expressed in the form of disturbances in the functioning of the digestive system. A person will suffer from diarrhea, nausea, vomiting, his appetite worsens, and his taste may be distorted. As a rule, such discomfort is observed only in the first days from the start of therapy.
To minimize the likelihood of developing side effects, treatment should be started with the lowest doses.
If the patient develops skin rashes and itching, then this requires a medical consultation, as it may indicate an individual drug intolerance.
In the course of long-term treatment, a deficiency in the body of vitamin B12 is possible.

During childbearing and during breastfeeding, the drug is not prescribed to women. However, it is often used to treat polycystic ovary syndrome. If at this time the woman becomes pregnant, then nothing terrible will happen. It will be necessary to stop taking the drug immediately after she finds out about her situation.

In case of an overdose, hypoglycemia does not develop, but lactic acidosis can occur (in about 32% of cases). The person must be urgently hospitalized. Dialysis is required to quickly remove the drug from the body. In parallel, symptomatic treatment is carried out.

With the simultaneous appointment of Metformin with insulin, a sharp decrease in blood sugar levels is possible. It can also react with drugs to lower blood pressure and drugs to treat heart disease.

Release form of the drug Metformin, storage conditions.

The drug can be found in dosages of 500, 850 and 1000 mg. It is produced in tablet form.
The ambient temperature must not exceed 25 C. The shelf life varies from 3 to 5 years.

Prediabetes and Metformin.

Metformin can be taken by obese people with prediabetes. This will reduce the likelihood of developing type 2 diabetes.

First you need to try to lose weight through diet. If the effect is not achieved, then drugs can be connected. In addition to diet, a person needs to increase his physical activity: exercise, walk more, and jog. In parallel, it is necessary to monitor the level of blood pressure, as well as the level of sugar in the blood, including on an empty stomach.

How long should a course of treatment with Metformin take?

Metformin is not a drug that is prescribed in courses. It is taken throughout life, without interruption, daily.

If a person develops diarrhea or other digestive disorders, then this is not a reason to stop treatment. It is possible that you need to reduce the dosage for a while.

A blood test should be done once every 6 months to determine the level of vitamin B12 in the body. If there is a deficiency, then it should be taken separately. There is also a recommendation to take vitamin B12 as a preventive measure.

Diet and intake of Metformin.

For weight loss and during diabetes management, a low-carb diet should be followed. It is not enough to simply cut down on daily calories and fat intake – this will not keep sugar levels under control. What’s more, a low-calorie diet can help increase your appetite, which can lead to overeating, breakdowns and weight gain.

If you do not reduce the amount of carbohydrates consumed, then it will not be possible to achieve a therapeutic effect with the help of taking pills and even with the help of insulin injections. Eating the right foods will help you stay full and prevent obesity.

Which drug to choose: Metformin, Siofor or Glucophage?

Glucophage is an original drug based on metformin. Siofor and other drugs are its analogues.

Glucophage Long is a long-lasting product. Its use is less likely to provoke the development of side reactions in the form of diarrhea than conventional drugs based on metformin. “Glucophage Long” is taken before bedtime, which will prevent the morning jump in blood sugar.

The cost of the drugs “Glucophage” and “Glucophage Long” is not high. Therefore, it makes no sense to switch to their counterparts. You won’t be able to save a lot.

Which brand is best used for the treatment of diabetes and obesity?

If you objectively look at the situation, then it is best to give preference to the original drugs – “Glucophage” and “Glucophage Long”. They are produced in France. Manufactured by Merk. Siofor and other metformin-based drugs are produced in the CIS countries.

What is the difference between Metformin and Formetin?

There is no difference. Formetin is a metformin-based drug produced in Russia. Its production is occupied by the Pharmstandard company. The dosage of the drug is 500, 850 and 1000 mg. The cost of Formetin is lower than the cost of Glucophage, but the difference is not great.

Metformin and Glyformin – what’s the difference?

Glyformin is another analogue of the original drug Glucophage. It is also based on metformin. The drug Glyformin is produced by the Russian company Akrikhin. There is no difference in price between the original and the analogue.

Regular Metformin vs Sustained-release Metformin – what’s the difference?

If a person takes regular metformin, then the drug is absorbed very quickly. Already 4 hours after its intake, the maximum concentration of the main active substance is observed in the blood. The drug is prescribed 3 times a day with meals.

When a person takes long-acting metformin, the drug is absorbed longer, but it will also last longer. The drug is prescribed once a day, before bedtime. This will help prevent a sharp rise in blood sugar in the morning.

Sustained-release metformin less often causes side effects in the form of disruption in the functioning of the gastrointestinal tract. However, it has less control over sugar levels throughout the day. Therefore, it is recommended for those people who have high fasting glucose levels. The original metformin drug is Glucophage Long. There are also analogs of this drug on the market with prolonged action.

The effect of Metformin on the liver. Fatty hepatosis and Metformin intake.

Metformin should not be taken for severe liver damage, such as cirrhosis or liver failure. In case of fatty liver hepatosis, its use, on the contrary, will bring significant benefits. In addition, the patient will need to follow a low carbohydrate diet. If you follow these recommendations, you will be able to improve your own well-being in a short time. Fatty hepatosis can be defeated with proper nutrition and taking metformin. In parallel, the person will begin to lose weight.

Reception of Metformin and hormonal background.

Metformin has no effect on male potency and on the level of testosterone in the blood.

With polycystic ovary syndrome, women have a high level of male sex hormones, as well as a violation of metabolic processes and insulin resistance. Taking metformin, for example Siofor, will get rid of the existing problem. The drug helps to normalize female hormonal levels and increases the likelihood of successful conception.

What drug should be taken instead of Metformin for renal failure?

It is prohibited to take Metformin in case of renal failure. It is not indicated for diabetic patients in whom the glomerular infiltration rate is reduced to 45 ml / minute.

With renal failure, you can take drugs such as Januvia, Galvus, Glurenorm. It is also possible to administer insulin injections. In any case, only a doctor should prescribe therapy for patients with such problems.

Metformin prolongs life – is it so?

Metformin definitely helps to prolong life in people with diabetes mellitus, as it prevents the development of severe complications of the disease.

As for the increase in life expectancy in those patients who do not suffer from diabetes, there is no scientific evidence for this fact. However, studies on this issue have already started.

You can also find reviews that treatment with Glucophage slows down aging. This is confirmed by people who do not take it for the treatment of diabetes.

Preventive use of Metformin and its dosage.

If a person suffers from obesity, then he can take Metformin prophylactically. This drug allows you to get rid of several kilograms of excess weight, as well as normalize cholesterol levels, which, in turn, is an excellent prevention of type II diabetes.

Before starting a prophylactic reception, you should study the instructions for use and make sure that there are no contraindications.

It is recommended to start taking Metformin at the age of 35-40 years, although there are no updated data on this. In addition to medication for weight management, you will need to follow a low-carb diet. It should be understood that the effect of the pills will be minimal if you continue to eat incorrectly. Foods containing refined sugars are especially harmful.

Obese people need to take Metformin at a dosage of 2550 mg per day. If the treatment is carried out with a drug with a prolonged action, then the daily dose should be 2000 mg. You need to increase it smoothly. During the first week, it will be enough to take 500-850 mg of the drug per day. This will allow the body to adapt to the drug.

If a person does not have a problem of excess weight, and he wants to take Metformin to prevent early aging, then it is enough to drink 500-1700 mg of the drug per day. There is no clarified information on this issue.

Metformin for weight loss.

Metformin allows you to lose weight without harm to your health, as the drug rarely causes serious side effects. In addition, it can help normalize blood cholesterol and glucose levels.

Given these facts, it shouldn’t come as a surprise that metformin is often used for weight loss. The experience of its reception is more than 50 years. Metformin-based drugs are manufactured by many pharmaceutical companies. This allows you to keep the price of the original drug Glucophage at a low level.

In order not to provoke the development of side effects, metformin should be taken in small doses (at the first dose of the drug). Before starting the fight against excess weight, you need to make sure that the person has no contraindications to the use of the drug.

How much body weight can you lose with Metformin?

If you do not rebuild your diet and do not play sports, then you will not be able to lose weight by more than 2-4 kg.

When, after 1.5-2 months from the start of taking metformin, there is no result and the weight remains at the same levels, this may indicate that a person has hypothyroidism. It is imperative that you consult a specialist and get tested for thyroid hormones.

Eating a low-carb diet in combination with metformin can lead to significant weight loss of 15 kg or more. To maintain these results, you need to take Metformin on an ongoing basis. After giving up pills, the weight may return.

What allows you to lose weight faster: Metformin or Glucophage?

Glucophage is a metformin-based drug. Moreover, it is an original drug. Therefore, with its help, it is quite possible to lose weight. If Glucophage leads to the development of severe diarrhea, then you can try taking the drug Glucophage Long.

Metformin and hypothyroidism.

Metformin can be taken for hypothyroidism, as this disease is not indicated as a contraindication. It is also allowed to be used in conjunction with drugs for the treatment of hypothyroidism. It is possible that this will allow you to lose weight and improve your well-being. However, a doctor should be involved in treating hypothyroidism, and metformin has no effect on the course of the disease.

Metformin and the treatment of type 2 diabetes.

Metformin is a type 2 diabetes drug that keeps glucose levels under control both after meals and on an empty stomach. The use of metformin allows you to prevent the development of severe complications of the disease, to stop its progression and not to harm health. Metformin should not be viewed as a miracle cure for diabetes. Of course, there were cases when a person coped with obesity, and the disease receded, which made it possible to abandon the use of metformin, but such situations are rare.

If a person takes metformin regularly and for a long time, then this will normalize the level of sugar, cholesterol and triglycerides in the blood, as well as get rid of excess weight.

Metformin is a safe drug, therefore it is prescribed for the treatment of diabetes and obesity in children over 10 years of age. It is necessary to start taking the drug with a minimum dosage of 500-850 mg per day, gradually increasing the daily volume of the drug to 2250 mg. If the drug Glucophage Long is used for treatment, then a dose of less than 2000 mg should be taken per day.

Keeping diabetes and weight under control solely with the help of drugs will not succeed. The patient will need to follow a diet. Otherwise, diabetes will continue to progress and lead to severe complications.

Which metformin drug is best for lowering blood sugar?

For the treatment of diabetes mellitus, it is preferable to use Glucophage. This is an original drug at a cost affordable for most people. You can also take its analogue Siofor.

To prevent blood sugar from increasing in the morning, you can use the drug Glucophage Long. It is taken before bed, so it will work throughout the night. Insulin injections may be needed when this measure does not keep blood sugar stable. It must be remembered that the morning rise in blood glucose contributes to the development of complications of diabetes. Therefore, such leaps cannot be ignored.

If metformin gives me diarrhea or does not help, what can be used to replace it?

It is difficult to find a replacement for metformin – it is a unique substance for lowering blood sugar.

Therefore, first you need to try to prevent diarrhea, so as not to look for a substitute for metformin. For this, treatment should be started with low doses of the drug. This will allow the body to adapt to the drug and not react to it with a malfunction of the digestive processes.

Less commonly, a long-acting drug causes diarrhea. Therefore, for a while, you can replace the usual Metformin tablets with them.

If the drug does not lower blood sugar, then it is likely that the person will develop type 1 diabetes. At the same time, the pancreas has exhausted all its reserves and is no longer able to produce insulin. Then you need to switch to injections of this hormone. Otherwise, the person may die from complications of diabetes. Pills must be discarded.

In a situation where metformin lowers blood sugar levels, but this is not enough, treatment can be supplemented with insulin injections, but in small doses.

If a person has a low body weight, but he develops diabetes, then such patients should be immediately prescribed insulin. Sugar-burning drugs will not allow you to cope with the disease.

Taking metformin increases blood sugar, what is the reason?

Metformin will not help lower blood sugar if type 2 diabetes is severe or when a person has type 1 diabetes. In this case, insulin injections will be required, as well as adherence to a diet.

The doctor may recommend replacing or supplementing metformin preparations with such drugs as: Diabeton MV, Amaryl, Manil, etc. Also, the latest generation drugs are already available for purchase, including: Januvia, Galvus, Forsiga, Jardins, etc. If their use is also not allows you to achieve the desired effect, then you should switch to insulin injections. Insulin therapy should not be abandoned. Moreover, taking medications can reduce the insulin dose by 2-7 times. This will allow you to keep sugar in control and not harm your health.

Diabetes treatment with Metformin and insulin injections.

Most often, metformin preparations are prescribed in a complex scheme with insulin injections. This will allow you to fix the sugar level at around 4.0-5.5 mmol / l.

Only with the help of diet and oral intake of sugar-burning drugs can cope with diabetes, provided that it is at an early stage of its development. Otherwise, low doses of insulin are required. This is true for patients whose blood sugar level does not drop below 6.0-7.0 mmol / l. With these rates, complications of diabetes will progress, although not very quickly.

If we consider the steps for treating diabetes mellitus, then you should first try to correct the existing violation with the help of a dietary diet and exercise. Only then do they switch to taking sugar-burning drugs. When the effect cannot be achieved, insulin injections are indicated. The insulin dosage will need to be reduced by 25% if a person is receiving metformin drugs in parallel. Excessive doses of insulin against the background of treatment with sugar-burning agents threaten the development of hypoglycemia.

In addition to the above therapeutic measures, patients with diabetes need to play sports. Jogging or, as it is also called, qi-running helps to control the disease well. You can also diversify your physical activity with Scandinavian walking.

How to take Metformin?

Metformin is taken with food to reduce the risk of side effects.

Tablets that have a prolonged effect should be taken whole without chewing. They contain a cellulose matrix, which is responsible for the slow release of the main active ingredient. The breakdown of such a matrix occurs in the intestine. In this case, it is possible to change the consistency of the stool, but without the development of diarrhea. This does not pose any health hazard.

Can I take metformin without consulting a doctor?

Metformin drugs are available over the counter without a prescription, so a person can purchase them without first visiting a doctor. Before using the drug for the first time, you need to make sure that the patient has no contraindications to its use. It is best to take a blood test for this. It will assess the performance of the liver and kidneys. Such tests must be taken at least once every 6 months. It is also important to control the level of cholesterol in the blood and the level of blood pressure, which will make it possible to prevent the development of severe cardiovascular pathologies.

How much is the maximum daily dose of metformin?

For both weight loss and type 2 diabetes, the patient is prescribed a daily dose of 2550 mg of metformin. In this case, a person will need to take 1 tablet of the drug 3 times a day. The dosage of the drug is 850 mg.

If a prolonged-release drug is used for treatment, then the maximum daily dose is 2000 mg. To do this, take 4 tablets of 500 mg of Glucophage Long before bedtime.

The first doses of the drug should be minimal: 500 or 850 mg. Then, monitoring the reaction of the body, the dosage is gradually increased. Slow adaptation will prevent the development of severe complications from the digestive system.

If a person decides to take metformin to increase life expectancy, then it is recommended to observe a dosage of 500-1700 mg per day, but no more.

How long does the effect last?

Sustained-release metformin works for 8-9 hours. Regular metformin tablets last no more than 6 hours. If the next dose was taken before the time the previous dose is in effect, then don’t worry. It will not harm your health. It is important to ensure that no overdose occurs. To do this, you should not take the drug in an amount exceeding the daily dose.

When is it better to take metformin: morning, afternoon or evening?

The long-acting drug is taken at night. This allows you to keep your blood sugar levels normal even in the morning, on an empty stomach.

Conventional metformin tablets are taken in the morning, afternoon, and evening, with breakfast, lunch and dinner.

Can metformin be combined with statins?

Metformin can be taken with statins, which help lower blood cholesterol levels. If in parallel a person adheres to a diet, then it will be possible to normalize not only cholesterol levels, but also triglycerides, and the atherogenic coefficient. Moreover, taking metformin and adhering to a diet over time may allow you to stop taking statins. A menu with a low carbohydrate content will make it possible to remove excess fluid from the body, get rid of edema, and lower blood pressure. Therefore, doctors recommend gradually reducing the dosage of drugs for the treatment of cardiovascular pathologies, and then you can completely abandon them. It is possible that it will be possible to stop treatment with diuretic drugs.

Can Metformin be combined with alcoholic beverages?

During treatment with metformin drugs, it is permissible to consume small doses of alcoholic beverages. However, you need to monitor the amount of alcohol you drink, it is forbidden to get drunk.

There is no need to make time intervals between taking the medicine or drinking alcohol. That is, you can drink alcohol almost immediately.

If you do not follow the dosage and drink too much alcohol, then for diabetics this threatens the development of lactic acidosis. This is a serious condition that can be fatal. Therefore, alcohol abuse is dangerous to health.

Reviews about the drug Metformin.

You can find many positive reviews about the use of metformin for the treatment of diabetes and obesity. Most often, both patients and doctors recommend the use of Glucophage and Glucophage Long as original medicines. In parallel, you need to adhere to a diet that will help lower blood sugar levels.

Negative reviews are most often left by people who do not follow a low-carb diet and lead an unhealthy lifestyle. In this case, it will not be possible to cope with the disease even with the help of medicines.

You can also find positive reviews on the use of metformin with sulfonylurea derivatives, since such a scheme contributes to a rapid decrease in blood sugar levels. However, if this treatment is followed for a long time, there is a risk of depletion of the reserves of the pancreas with the transition of type 2 diabetes to type 1 diabetes.

Most patients indicate that Glucophage is less likely to cause side effects in the form of digestive upset. Therefore, it is better to choose original drugs based on metformin, rather than its analogues. When combined with diet and exercise, taking metformin can help you lose weight.