- 1 What is Metformin? Metformin Ingredients
- 2 How to Buy Metformin 500mg Tablets Online? Cheap Metformin Price
- 3 Metformin Price
- 4 Can Metformin Cause Constipation? Metformin and Diarrhea
- 5 Allergic Reaction to Metformin. Metformin Side Effects
- 6 Glucophage vs Metformin: Comparison. Another Name for Metformin
- 7 Januvia vs Metformin. Metformin Alternatives
- 8 Metformin and Ovulation. Metformin for Fertility During PCOS
- 9 Metformin 500 mg – action in type 2 diabetes.
- 10 Metformin 500 – indications for the use of the drug.
- 11 Metformin – drugs and dosage (European countries).
- 12 Metformin 500 mg – effects and clinical efficacy.
- 13 Metformin – side effects and contraindications.
What is Metformin? Metformin Ingredients
Metformin is released in pills for the oral use that have enteric coating. Every pill contains the active ingredient Metformin hydrochloride in the dose of 500 mg, 850 mg, and 1000 mg.
Besides the main active ingredient, the pill contains:
- Crospovidone and povidone K90 is a non-active ingredient which improves the absorption of the active ingredients in the intestine.
- Calcium/magnesia stearate is a lubricant which improves the conductivity of the pill in the intestine, reduces the cuts and affections of the pills, keeps the required amount of the active ingredient.
- Talc has the same properties as stearate.
None auxiliary ingredient does not influence on the therapeutic properties of Metformin, however, if a patient has intolerance of one of the ingredients, he/she may have an allergic reaction. Therefore, it is important to know the content before taking the pill.
How to Buy Metformin 500mg Tablets Online? Cheap Metformin Price
How to get metformin? To buy Metformin 500 mg online, 15 minutes are needed. To place an order correctly, use the customer support. You will be provided a personal help from the representatives of the pharmacy who will tell you how to avoid mistakes during the order.
You will be provided a detailed information about a cost of Metformin, conditions of the delivery, and possible payment methods.
To buy Metformin 500 mg tablets online, it is necessary to fill out a standard blank and indicate your contacts. Your package will be sent to the indicated address within 24 hours after the placing the order. The package will be delivered by a method you have chosen.
Below we will present to your attention the prices of the drug Metformin. This is one of the cheapest prices on the pharmaceutical market.
Metformin 500 mg tablet:
90 pills – $33.39 ($0.28 per pill);
180 pills – $55.65;
360 pills – $100.17.
Can Metformin Cause Constipation? Metformin and Diarrhea
Metformin is often associated with the gastro-intestinal side effects than most other antidiabetic drugs. Patients may have such symptoms as intestinal colic, poor appetite, and flatulency at the beginning of the treatment.
However, the reaction of the intestine is individual, and one patient may have diarrhea, and others – constipation.
Metformin can cause a constipation which lasts for several days. However, during the use of the low doses, this symptom is temporal and is not regular. Constipations often appear because patients do not change diet and consume a lot of carbohydrates.
In case of the constipation, during the use of Metformin, it is recommended to increase a consumption of fibers, and all fast carbs should be replaced by slow ones. There are cases when patients have diarrhea for a couple of days after the constipation. These symptoms pass in 1-2 months, and the gastro-intestinal tract regulates its work.
Allergic Reaction to Metformin. Metformin Side Effects
An allergic reaction to Metformin is diagnosed seldom but these cases happen. It happens due to two reasons:
- Individual intolerance of Metformin;
- Intolerance of one of the auxiliary ingredients.
The general symptoms of the allergic reaction to Metformin are skin rash, itching, redness of the skin. The allergy is characterized by a light course, but if the medication is not replaces, the body intoxication will grow, and it may cause urticarial and other severe allergic reaction.
- Patients are prescribed another hypoglycemic product which contains another active ingredient during the intolerance of Metformin. The allergy is often regular and does not pass in years.
- In case of the intolerance of the auxiliary ingredients in the pill or its coat, it is necessary to find out what ingredient causes an allergic reaction and find the pills of Metformin that do not contain it.
There are many manufacturers of Metformin that use various auxiliary ingredients in the pills, and they may vary. Therefore, it is not difficult to find the pills without an ingredient that causes an allergy.
Glucophage vs Metformin: Comparison. Another Name for Metformin
Metformin is the name of the active ingredient which is taken to reduce the sugar level during diabetes mellitus type 2. This medication is supplied to the market under various trade names, one of which is Glucophage.
Glucophage is a brand name of Metformin, a manufacturer of which is a pharmaceutical company Merck. However, many pharmaceutical companies from Europe and Asia use Metformin to create Generics.
Glucophage and Generic Metformin have the identical mechanism of the action because they contain the same amount of the active ingredient.
However, there are differences between Glucophage and Generics Metformin:
- First, the appearance of the pills. They may have various shape, color, and engraving. But they will contain the original formula of Metformin.
- Secondly, auxiliary non-active components. Yes, many doctors prefer using Metformin because it may have such non-active ingredients that improve the absorption of the active ingredients in the intestine and their bioavailability.
- Thirdly, a cost. Merck Company invests million dollars into the marketing of the brand name Glucophage and covers its expenses by means of a high cost of the pills. Generic Metformin may cost by 3-4 times lower only because it is most popular ingredient for the treatment of diabetes mellitus, and it does not need the advertisement. The absence of the expenses in the manufacturers of Metformin on the marketing allows reducing the cost of the pills.
It is weird but there are cases when patients state that they have not got any side effects during the use of Metformin, but when they take Glucophage, the side effects have appeared. There are other cases. It happens because the pills from every manufacturer has various auxiliary non-active ingredients that influence on the tolerance of the pills.
Taking Metformin produced by another manufacturer, it is possible to get rid of the side effects and increase the efficiency of the treatment of diabetes mellitus type 2. These cases are often in the medical practice, and therefore the original expensive drug is not always better than the cheap analogue.
Januvia vs Metformin. Metformin Alternatives
One of the main competitors of Metformin on the market of the hypoglycemic products is Januvia. It is a medication of the new generation, differs from Metformin by the content and a mechanism of the pharmacological action.
Januvia selectively blocks Dipeptidyl peptidase-4 (DPP4), so that a concentration of two hormones from the incretins group is increased: pancreatic duct, and gastric inhibitory peptide. These hormones are responsible for the synthesis of insulin as a reaction to the glucose in the blood.
This way, Januvia favors a fast response of the pancreatic gland during the high level of glucose in the blood, and the insulin synthesis is increased. Taking one therapeutic dose of Januvia acts within 24 hours, and it leads to the increase of the plasma concentration of insulin.
But Januvia does not influence on the insulin-resistance, and it is proved that the efficiency of this drug is reduced during the intense resistance of the tissues to insulin.
Metformin has another mechanism of the action and does not increase the insulin synthesis. But it is more effective because it inhibits the resistance to insulin and favors a further reduction of the glucose level in the blood.
It is pointless to compare Januvia vs Metformin because these medications should be taken during various types of diabetes.
- If there is enough insulin but it is not able to feed the cells of the glucose, it is effectively to take Metformin.
- If a production of insulin is not enough, and a sensitivity of the cells to it is normal, it is effectively to take Januvia.
Januvia may become an alternative to the injectable insulin which is used during the deficit of insulin but it cannot be an alternative to Metformin.
The clinical studies show that a combination of Januvia and Metformin during the 3-4 degree of diabetes mellitus helps to achieve the maximal and fast effect during the low number of the side effects. A risk of the hypoglycemia is lower during such combination of the medication than during the use of Metformin and insulin injections.
Metformin and Ovulation. Metformin for Fertility During PCOS
There are clinically proved facts confirming that Metformin is able to restore ovulation during the polycystic ovarian syndrome (PCOS). In case of this syndrome, a resistance to insulin and the disorders in the pancreatic gland often appear. A lot of tissues in the body produce a resistance to insulin, whilst the tissues of ovaries keep the sensitivity of the tissues. The excessive amount of insulin during the polycystic ovarian syndrome leads to the disorder of the hormone production and an ovulation disorder.
Metformin is one of the most effective drugs to influence on the ovulation in women with the polycystic ovarian syndrome (pcos). It acts on a cause of the disease restoring the sensitivity of the tissues to insulin. The work of the ovaries and ovulation are restored during the normal level of insulin.
Many scientists differ in opinion but the practical studies and reviews of women tell that Metformin really helps to restore ovulation. But the medication works only if the ovulation is affected because of the ovaries dysfunction, due to the insulin-resistance.
The most effective results are achieved during the simultaneous use of Metformin and Clomiphene. In this case, Metformin acts on a cause of the pathology, and Clomiphene provides a stimulating action in order to relieve the recovery of the ovary functions.
Metformin 500 mg is a medication used to treat and prevent type 2 diabetes when there is a high risk of developing the disease. The drug is also used in the treatment of polycystic ovary syndrome, although in many countries the drug is not officially approved for this purpose.
When receiving a prescription from an endocrinologist, patients are often interested in how metformin works and what side effects it has.
Metformin 500 mg – action in type 2 diabetes.
Metformin is a widely used drug that has clear benefits in terms of affecting glucose metabolism and minimizing complications associated with diabetes. The mechanism of action of this drug is multidirectional, and to be honest, it has not yet been fully understood. But the number of proven effects already speaks of the high value of this remedy.
The key target organ for this drug is the liver. The improvement in glycemic value is due to the effect of the active substance on the process of gluconeogenesis, which consists in the conversion of amino acids and other compounds into glucose. On the other hand, the absorption of sugar in the small intestine is inhibited. Supplements hypoglycemic activity by increasing peripheral glucose uptake.
A number of other benefits of using this hypoglycemic drug have also been proven. Metformin reduces the adhesion of blood cells to the wall of blood vessels and the secretion of endothelial activation factors, preventing the development of atherosclerosis.
Reducing the concentration of pro-inflammatory cytokines and the amount of free oxygen radicals causes an anti-inflammatory effect.
Metformin is known for its beneficial effects on life expectancy and on disorders caused by increased insulin resistance. For this reason, it is classified as a first-line drug in the group of effective drugs for the treatment of type 2 diabetes.
Metformin 500 – indications for the use of the drug.
Metformin 500 mg has many therapeutic uses. According to the latest guidelines, it should be prescribed at every stage of the treatment for type 2 diabetes. It can be used alone or in combination with other oral hypoglycemic agents or insulin.
Metformin is indicated as a first-line drug, especially for obese patients who have not been helped by diet and exercise to achieve adequate glycemic control.
The drug can also be prescribed to patients with diabetes in combination with diagnosed cardiovascular disease or chronic kidney disease. Metformin and its analogs are perfectly combined with other drugs in a triple combination therapy regimen without insulin.
The substance is also used in polycystic ovary syndrome, as it has been shown that insulin resistance with secondary hyperinsulinemia is among the causes of this disease. In addition, the therapy reduces overweight and obesity, which are very common in women with PCOS.
The drug Metformin is also included in the list of pharmacological agents that promote weight loss in people with diabetic disorders. Many studies have seen a 2 kg weight loss after the first year of treatment. But the medicine cannot be used as the only means for losing weight.
Metformin – drugs and dosage (European countries).
Metformin is available in tablets containing 500 mg, 850 mg and 1000 mg of the active substance. All medications are available with a prescription, which can be obtained from an endocrinologist.
There are two types of pills:
1. Standard tablets, for example Siofor (Metformax);
2. Slow-release tablets, eg Glucophage (Metformax SR).
Standard drugs work quickly. Depending on the dose, you may need to take them several times a day. Usually, therapy begins with the lowest dosage, which is modified by the endocrinologist based on the obtained blood sugar measurements after 10-15 days. The maximum daily doses are 2000-3000 mg in 2-4 doses.
Slow-release tablets dissolve slowly and do not need to be taken frequently. Usually, one serving of the drug is sufficient to take with dinner.
For standard release formulations, a slow dose escalation is recommended. This reduces the likelihood of side effects. But getting carried away with high dosages is pointless: studies show that increasing the dose from 2,000 to 3,000 mg improves diabetes control only slightly.
Metformin 500 mg – effects and clinical efficacy.
In recent years, type 2 diabetes has been increasingly recognized as one of the main risk factors for cardiovascular disease. The most common complication of this disease among Europeans is atherosclerosis, which occurs 2-5 times more often in people with diabetes than in healthy people.
These observations indicate that diabetes management requires interventions that not only lower blood glucose levels, but also have hypoglycemic and ameliorating effects on:
5. insulin resistance.
Taking metformin 500 mg in the right doses may be most beneficial in this regard. It has been shown to lower glucose, triglyceride levels and help reduce weight.
Insulin resistance is the main metabolic disorder in obesity and type 2 diabetes, according to research. Thus, the well-known effect of metformin on the reduction of insulin resistance makes this drug an excellent agent for preventing the progression of impaired glucose tolerance and reducing cardiovascular mortality.
Metformin – side effects and contraindications.
Side effects of taking metformin 500 mg most often occur only at the beginning of therapy and in most cases disappear on their own after a while, after the body gets used to the drug.
At the beginning of treatment, patients often complain about:
- violation of taste;
- an appetite disorder;
- abdominal pain.
The use of the drug in the norms prescribed by the endocrinologist does not carry the risk of hypoglycemia. But you need to be careful when taking several antidiabetic drugs at the same time. The combination of metformin with other hypoglycemic drugs or insulin can cause glucose levels to drop to life-threatening levels.
The simultaneous use of metformin with alcohol is also dangerous – lactic acidosis may develop.