Does Metformin Cause Weight Loss? Metformin Weight Gain
A risk of the development of chronic diseases including disorders of the cardiovascular system and diabetes mellitus type 2 actively grows during the increase of the body mass index.
Therefore, it is clear that any measures taken for the reduction of the excessive body weight leads to the significant and various improvement of the human health. The studies with the running time of 12 years among women with the body mass index more than 30, at the age of 40-64 have found out that a reduction of the body weight is by 10% from the current level, and it leads to the decrease of the cardiovascular diseases by 9%, diabetes mellitus type 2 – by 44%.
A risk of the total mortality during the weight loss by 10-15% is reduced by 20%, and it tells about the use of the obesity treatment, and vital necessity.
The main ways to reduce the excessive body weight by the pharmaceutical remedies are well described in the clinical studies. Yes, doctors think that there are two types to effectively lose weight:
- A pharmaceutical way to reduce the appetite;
- A reduction of the calorie supply (including fats and carbohydrates).
Traditionally Metformin is not a medication for the obesity treatment, and its main pharmacological property consists in a reduction of the glucose level in the blood. As the obesity and diabetes mellitus type 2 are concomitant diseases, it has been detected that the use of Metformin during the treatment of diabetes helps to reduce the body weight.
The Metformin mechanism of the reduction of the body weight is conditioned by several essential mechanisms:
- Metformin slows down the acceleration of the fatty acids;
- Metformin reduces the speed of the carbs uptake in the intestine;
- Metformin improves the consumption of the glucose by the muscles tissues;
- Metformin regulates metabolism;
- Metformin reduces the free insulin in the blood.
Metformin is inferior to the specialized drugs for the obesity treatment such as Sibutramine and Orlistat but unlike these medications, it provides a soft and safe action.
As Metformin inhibits the insulin-resistance, the pancreatic gland does not synthesize the amount of insulin. A reduction of insulin inhibits the hunger. Patients with diabetes mellitus often experience the excessive appetite, so that they have to eat more.
Moreover, the drug accelerates the transformation of the glucose and the supplies of the fatty tissue into the energy, in the muscle fibers. The effect grows because a part of carbs is processed in the intestine, so that a light deficit of the exogenous glucose is created in combination with a diet. The body has to spend the fat for the energy during this deficit.
This way, Metformin is able to lower the glucose level in the blood, and slightly reduce the amount of the fat.
How to Lose Weight with Metformin?
Many people think that Metformin may be used as the basic product to lose weight. However, this medication is indicated patients with diabetes mellitus, who have the body mass index more than 28.
There are many preconditions that make Metformin to work for the weight loss. It is a high sugar level in the blood, the excessive amount of insulin, and metabolism disorder. If a patient does not have it, but he/she wants to lose weight, it is pointless to take Metformin.
To lose weight with Metformin, it is necessary to follow to the simple rules:
- A regular use of the pills for at least 2 times per day;
- A daily dose should be at least 1000 mg;
- It is necessary to achieve the reduction of the glucose level in the blood by 12%;
- Follow the balanced diet with a low content of the carbohydrates;
- Increase the physical activity.
Metformin works as a stimulator of the natural processes in the weight loss, and therefore the non-observance of any of these items will not give you a good result. The pills will create the conditions when the weight loss will be faster and lighter, but the main task lies on a patient.
It is worth noting that patients having the result in a control of diabetes mellitus type 2 have recorded the termination of the progress during the weight loss due to Metformin. It gives the right to assume that the weight loss goes naturally, without pharmaceutical methods, and Metformin will be as an additional support.
Other Ways to Lose Weight
A weight loss is a complicated and a long-term process. Many patients do not have enough patience and strength to cope with the obesity naturally, and they try strong pills. But all these strong medications are contraindicated for patients with diabetes mellitus type 2. The only approved medication is Metformin.
However, there are other ways to reduce the excessive body weight that give a good and fast effect in combination.
Patients with diabetes mellitus better have moderate cardio. The weight trainings may cause a temporal increase of the glucose level in the blood in comparison with cardio training that usually cause a decrease. Therefore, running, walking, bicycling, and others will perfectly do to reduce weight. The important key is to keep the pulse within 120-130 beats per minute.
But remember that the trainings with additional weight increase a sensitivity of the tissues to insulin. Therefore, it is recommended to add the 2-3 weight trainings per month. It will help to reduce the excessive weight and increase the muscle mass that will consume more energy and calories.
A decrease of the amount of the daily calories leads to the development of the glucose deficit in the blood, and it makes the body to look for the energy in the fatty tissues. Diet should not be strict (less than 1000 Kcal per day) because it may cause hypoglycemia during diabetes mellitus.
It is preferable to reduce the general amount of calories by means of the carbohydrates that are transformed into the glucose, whilst a lot of proteins and fibers should be consumed.
Recovery of the endocrine function
Diabetes mellitus type 2 and obesity influence on the endocrine function. The slowing of the metabolism leads to the fact that a human is not able to gain the excessive muscle mass during diet. To have the effective treatment of the obesity, it is necessary to check the level of all hormones and find a cause of the disorders. Restoring the endocrine function, it is possible to accelerate the metabolic processes, reduce the glucose level in the blood and the body weight.