Metformin and weight Loss. Does Metformin cause weight gain?

Does Metformin cause weight loss? Metformin and weight gain.

A risk of the development of chronic diseases including disorders of the cardiovascular system and diabetes mellitus type 2 actively grows during the increase of the body mass index.

Does Metformin Cause Weight Loss

Therefore, it is clear that any measures taken for the reduction of the excessive body weight leads to the significant and various improvement of the human health. The studies with the running time of 12 years among women with the body mass index more than 30, at the age of 40-64 have found out that a reduction of the body weight is by 10% from the current level, and it leads to the decrease of the cardiovascular diseases by 9%, diabetes mellitus type 2 – by 44%.

A risk of the total mortality during the weight loss by 10-15% is reduced by 20%, and it tells about the use of the obesity treatment, and vital necessity.

The main ways to reduce the excessive body weight by the pharmaceutical remedies are well described in the clinical studies. Yes, doctors think that there are two types to effectively lose weight:

  • A pharmaceutical way to reduce the appetite;
  • A reduction of the calorie supply (including fats and carbohydrates).

Traditionally Metformin is not a medication for the obesity treatment, and its main pharmacological property consists in a reduction of the glucose level in the blood. As the obesity and diabetes mellitus type 2 are concomitant diseases, it has been detected that the use of Metformin during the treatment of diabetes helps to reduce the body weight.

The Metformin mechanism of the reduction of the body weight is conditioned by several essential mechanisms:

  • Metformin slows down the acceleration of the fatty acids;
  • Metformin reduces the speed of the carbs uptake in the intestine;
  • Metformin improves the consumption of the glucose by the muscles tissues;
  • Metformin regulates metabolism;
  • Metformin reduces the free insulin in the blood.

Metformin is inferior to the specialized drugs for the obesity treatment such as Sibutramine and Orlistat but unlike these medications, it provides a soft and safe action.

As Metformin inhibits the insulin-resistance, the pancreatic gland does not synthesize the amount of insulin. A reduction of insulin inhibits the hunger. Patients with diabetes mellitus often experience the excessive appetite, so that they have to eat more.

Moreover, the drug accelerates the transformation of the glucose and the supplies of the fatty tissue into the energy, in the muscle fibers. The effect grows because a part of carbs is processed in the intestine, so that a light deficit of the exogenous glucose is created in combination with a diet. The body has to spend the fat for the energy during this deficit.

This way, Metformin is able to lower the glucose level in the blood, and slightly reduce the amount of the fat.

How to lose weight with Metformin?

Many people think that Metformin may be used as the basic product to lose weight. However, this medication is indicated patients with diabetes mellitus, who have the body mass index more than 28.

How to Lose Weight with Metformin?

There are many preconditions that make Metformin to work for the weight loss. It is a high sugar level in the blood, the excessive amount of insulin, and metabolism disorder. If a patient does not have it, but he/she wants to lose weight, it is pointless to take Metformin.

To lose weight with Metformin, it is necessary to follow to the simple rules:

  • A regular use of the pills for at least 2 times per day;
  • A daily dose should be at least 1000 mg;
  • It is necessary to achieve the reduction of the glucose level in the blood by 12%;
  • Follow the balanced diet with a low content of the carbohydrates;
  • Increase the physical activity.

Metformin works as a stimulator of the natural processes in the weight loss, and therefore the non-observance of any of these items will not give you a good result. The pills will create the conditions when the weight loss will be faster and lighter, but the main task lies on a patient.

It is worth noting that patients having the result in a control of diabetes mellitus type 2 have recorded the termination of the progress during the weight loss due to Metformin. It gives the right to assume that the weight loss goes naturally, without pharmaceutical methods, and Metformin will be as an additional support.

Other ways to lose weight.

A weight loss is a complicated and a long-term process. Many patients do not have enough patience and strength to cope with the obesity naturally, and they try strong pills. But all these strong medications are contraindicated for patients with diabetes mellitus type 2. The only approved medication is Metformin.

However, there are other ways to reduce the excessive body weight that give a good and fast effect in combination.

Physical trainings

Patients with diabetes mellitus better have moderate cardio. The weight trainings may cause a temporal increase of the glucose level in the blood in comparison with cardio training that usually cause a decrease. Therefore, running, walking, bicycling, and others will perfectly do to reduce weight. The important key is to keep the pulse within 120-130 beats per minute.

But remember that the trainings with additional weight increase a sensitivity of the tissues to insulin. Therefore, it is recommended to add the 2-3 weight trainings per month. It will help to reduce the excessive weight and increase the muscle mass that will consume more energy and calories.

Low-carb diet

A decrease of the amount of the daily calories leads to the development of the glucose deficit in the blood, and it makes the body to look for the energy in the fatty tissues. Diet should not be strict (less than 1000 Kcal per day) because it may cause hypoglycemia during diabetes mellitus.

It is preferable to reduce the general amount of calories by means of the carbohydrates that are transformed into the glucose, whilst a lot of proteins and fibers should be consumed.

Recovery of the endocrine function

Diabetes mellitus type 2 and obesity influence on the endocrine function. The slowing of the metabolism leads to the fact that a human is not able to gain the excessive muscle mass during diet. To have the effective treatment of the obesity, it is necessary to check the level of all hormones and find a cause of the disorders. Restoring the endocrine function, it is possible to accelerate the metabolic processes, reduce the glucose level in the blood and the body weight.

Metformin for weight loss.

Getting rid of extra pounds is a rather difficult task in physiological and psychological terms, since it requires significant efforts and a significant change in the usual way of life. Therefore, not only nutritionists, but also people who want to lose weight are constantly looking for the easiest ways to normalize body weight.

Recently, the use of medicines for weight loss has become popular. The drugs may not be specifically designed for weight loss, but show good fat burning results in the treatment of the underlying disease. One such drug is Metformin, a pill prescribed by doctors to lower glucose levels in diabetes. Athletes and bodybuilders were the first to take Metformin for weight loss. Then, having received numerous positive reviews, the drug went far beyond medical and sports uses.

How does Metformin work for weight loss?

By itself, this substance is the only one of all oral antidiabetic agents that is approved for use in children, since it is made from natural plant materials. In addition to type 2 diabetes, these pills are used to treat non-alcoholic fatty liver disease and are currently being tested as a cancer prevention tool.

The mechanism of action of this substance on the process of losing weight is due to its ability to influence peripheral insulin resistance. With excess body weight, a decrease in sensitivity to insulin, a hormone that is produced by the pancreas and delivers glucose into the cells, almost always develops. When the perception of insulin by cells is disturbed, and glucose does not penetrate into them, the pancreas increases the production of insulin, which increases its level in the blood.

Because of this, lipid metabolism worsens and fat begins to be heavily deposited in reserves. The causes of insulin resistance in cells can be very different, but more often than not, excessive consumption of fast carbohydrates leads to this. Cells oversaturated with glucose begin to “defend” against it, refusing to accept insulin, which is becoming more and more, which makes it even more unacceptable for cells. A closed process is formed that leads to the development of obesity.

Metformin reduces insulin resistance and returns cells to their natural state. As a result, they begin to regularly absorb glucose, which normalizes insulin synthesis and stops the deposition of fat stores.

In addition to these properties, this substance has a number of positive effects that contribute to weight loss:

1. Metformin accelerates fatty acid oxidation chemical reactions;
2. Metformin reduces the absorption of carbohydrates in the digestive tract;
3. Metformin reduces cholesterol levels;
4. The drug slows down the production of glucose by the liver;
5. The drug stimulates lipid breakdown.

In addition, Metformin has a weak concomitant effect – a decrease in appetite. It is on him that most of those people who begin to use the drug for the purpose of losing weight rely on. However, this anorexigenic effect is so little expressed that it is practically not felt. Therefore, the use of pills to eliminate hunger is not justified.

American doctors conducted a series of experiments to determine the effect of Metformin on weight loss. About 2000 volunteers took part in it, divided into 3 groups, each of whom led a different lifestyle for 2 years:

1. Members of the first group ate properly and actively went in for sports (3 times a week), without taking any pills;
2. Members of the second group took a placebo and led a normal life without using additional weight loss methods;
3. Members of the third group also led the life of an ordinary average person and took Metformin pills for weight loss.

The lowest result was in the second group – they lost an average of 0.5 kg. In the third group, weight loss on tablets was about 2 kg. The members of the first group, who led a healthy active lifestyle, lost the most weight – they lost 5-6 kg.

The results of an experiment by American scientists have shown that Metformin does not work for weight loss without proper diet and exercise. Exceptions are of course possible. Some people with very large body weight lose 3-7 kg per week in the first months of taking the drug. However, with weight loss without further additional effort (severe dietary and exercise restrictions), this effect disappears.

Attention! Metformin is not a weight loss miracle cure that burns fat and eliminates appetite. The drug works only with lifestyle changes, including the transition to proper nutrition, physical activity and a positive attitude.

How to take Metformin slimming tablets?

Diet, sport and thought are the main components of the weight loss process, and pills are only its additional component, which can often be dispensed with. Direct indications for the use of Metformin for weight loss can only be associated with the presence of obesity against the background of diabetes mellitus. If there is no diabetes, but losing weight with pills is psychologically more comfortable, then this can also be done, but be sure to follow all the rules.

Method of using Metformin for fat burning.

Having decided to take Metformin for weight loss, you need to clearly understand how this is done correctly – in what doses and according to what scheme. Do not forget that initially the tablets are intended for patients with metabolic syndrome or diabetes, therefore, the instructions for use were developed by the manufacturer taking into account pathological changes in the body.

So, treatment for a child from 13 years old and an adult begins with 500 and 850 mg, respectively, taken with dinner or at night. To avoid adverse reactions, the dose is increased gradually – every 1–2 weeks by 500–850 mg.

The recommended dosage for patients is 1500 mg / day, taken in 2-3 doses, the maximum is 1700 mg / day according to the same regimen. For the prevention of obesity in diabetes mellitus, you need to take 200 mg / day.

If a healthy person is taking metformin for weight loss, the dosage should not exceed 1000 mg / day. You need to take pills according to the following scheme:

1. 500 mg during or after breakfast and dinner;
2. The tablet is swallowed whole (can be broken into 2 parts to facilitate swallowing) with water.

This dose is considered quite safe and minimizes the likelihood of adverse reactions. As the dosage is increased, the effect of weight loss will be greater, but it can be accompanied by unpleasant painful symptoms and a significant deterioration in well-being.

With good tolerance, it is allowed to increase the dose to 1500 mg / day – 500 mg each with breakfast, lunch and at night. In the first 3 days of admission, nausea and slight dizziness may occur, which is caused by a sharp decrease in blood glucose levels. If adverse reactions persist for 2 weeks, tablets should be discarded.

Some bodybuilders increase the dose of the drug to 2000-3000 mg / day, which is 2-3 times higher than the allowed rate for healthy people. Before drinking metformin, they inject insulin intramuscularly to reduce the aggressive effect of such large doses of the drug. But this weight loss scheme is extremely dangerous. In addition, insulin negates the desired effect of the pills, which makes it impractical to take them.

Important! The course of taking metformin slimming tablets should not exceed 20 days. Then a break for 1-2 months is required, which will avoid addiction. During the withdrawal period, you must continue to follow the diet and not reduce physical activity.

Diet for weight loss with Metformin.

The essence of the “metformin” diet is to exclude several categories of high-calorie foods from the diet:

1. Exclusion of sugar and flour products;
2. Exclusion of starchy or sugary vegetables and fruits (including potatoes, beets, carrots, bananas, grapes);
3. Exclusion from the diet of white rice, instant cereals;
4. Limited intake of fatty meat (pork, waterfowl).

Unlike other methods, the diet when taking metformin for weight loss does not prohibit the use of salt. It can be added to meals, but in moderation.

The list of permitted products includes:

1. Buckwheat, brown rice, lentils;
2. Vegetables and fruits (except prohibited);
3. Fish, seafood;
4. Meat of chicken, turkey, rabbit;
5. Kefir, cottage cheese.

The calorie content of the daily diet should be in the range of 1000-1200 kcal.

It should be borne in mind that taking these tablets often causes stomach upset, therefore, in order to avoid dehydration of the body, it is necessary to consume a sufficient amount of liquid – at least 2 liters. Better to give preference to pure water without gas, green tea and herbal infusions. You need to drink any drinks 20 minutes before meals (this will reduce appetite) and 40-60 minutes after meals.

Physical activity while losing weight.

Compliance with this diet alone will provide good weight loss results. But for a more pronounced and lasting effect, motor activity should be increased. For this, the following types of physical activity are perfect:

1. Jogging for 15 minutes;
2. Uncomplicated training complex;
3. Dance exercises to music.

When done regularly, these exercises will help speed up the processing of accumulated body fat and tone the muscles. If there is no time or desire to go in for sports, then you need to reduce the amount of calories consumed per day to 1000.

Contraindications for Metformin.

Before taking metformin for weight loss, it is recommended that you consult with a specialist and conduct a full examination to rule out the presence of diseases for which the drug is prohibited.

The following conditions may become a contraindication:

1. type 1 diabetes;
2. type 2 diabetes in the absence of insulin in the blood;
3. heart, renal, hepatic failure;
4. dehydration of the body;
5. acute infections;
6. pre-infarction and pre-stroke condition;
7. alcoholism, alcohol intoxication;
8. poisoning with lactic acid;
9. recovery period after surgery;
10. serious illness or injury;
11. anemia;
12. decreased appetite;
13. adherence to a strict diet;
14. pregnancy, breastfeeding;
15. intolerance to the components of the drug.

In the presence of chronic diseases, taking metformin for weight loss should be carried out under the supervision of a doctor, since the pills significantly increase the likelihood of an exacerbation.

What doctors say about weight loss with Metformin?

Among professional representatives of medicine, there is no consensus on whether it is possible to drink metformin for weight loss. Most doctors are inclined to believe that a healthy person (without metabolic syndrome) only needs to go on a diet and increase physical activity in order to normalize their weight. The use of a drug for weight loss is an extreme case. Despite its non-toxicity, it can cause serious disturbances in the digestive system and worsen general well-being. Therefore, the question of whether it is possible to take this medicine to normalize body weight should be decided individually in each case and always with the participation of a doctor. After all, this is an effective medication, and not just pills for weight loss.